Journal of Nanomedicine & Nanotechnology

TiO₂ nanodelivered cerebrolsyin: A novel therapeutic approach for brain pathology in CNS injuries

7^th World Nano Conference

June 20-21, 2016 Cape Town, South Africa

Hari Shanker Sharma, Dafin F Muresanu, Herbert Mössler and Aruna Sharma

Uppsala University, Sweden
University of Medicine & Pharmacy, Romania
Ever NeuroPharma, Austria

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Central nervous system (CNS) injuries either caused by trauma or metabolic insults induces brain pathology involving neuronal damages, astrocytic reaction and myelin vesiculation resulting in serious behavioral, psychological, mental and physical abnormalities. Thus, novel efforts are needed to contain neuronal cell damages and to restore loss of function by reducing agents causing neurotoxicity as well as enhancing endogenous factors helping in neurorepair or neuroregeneration. Thus, no single drug or compounds are capable to induce multifunctional aspects of CNS injuries and accomplishing the goal in patients for neurorehabilitation or neurorecovery. Keeping these views in mind multimodal drugs are the need of the hour. However, presence of the blood-brain barrier (BBB) in the CNS could reduce or prevent access of several drugs and compounds when given through systemic routes. Thus, effective concentration of drugs to reach injured brain tissues under traumatic, metabolic or ischemic insults is normally not possible for achieving the desired therapeutic goals. Recently nanodelivery of drugs has attracted great attention in medical science that allowed rapid penetration of active compounds in the brain and also to reduce their fast metabolism because of their binding to nanoparticles. Our laboratory is engaged in TiO₂ nanowired delivery of drugs in CNS injury and found great benefit of using this mode of nanodelivery as compared to the parent compounds in high doses. Cerebrolsyin (Ever Neuro Pharma, Austria) is a multimodal drug containing a balanced composition of several neurotrophic factors and active peptide fragments is thus quite suitable for nanodelivery to treat CNS injuries. Our experiments show that trauma either caused by impact injury or lesions of the brain or spinal cord results in exacerbation of pathophysiology and behavioral disturbances in diabetic or hypertensive rats as compared to identical trauma in healthy animals. In such circumstances TiO₂ nanowired delivery of cerebrolysin significantly protected the exacerbation of brain pathology and behavioral disturbances as compared to the parent compound. Our results have thus opened new avenues for the treatment of neurological diseases using multimodal compound cerebrolysin with nanowired approach to achieve good neuroprotection in patients suffering from several co-morbidity factors, a feature not addressed before by clinicians. These observations raise hope for the better treatment of brain-injured patients in near future in clinics. The possible mechanisms and functional significances of our findings will be discussed.

Biography :

Email: Sharma@surgsci.uu.se