Journal of Nanomedicine & Nanotechnology

Theranostic approach of hyaluronic acid-based nanoparticle

4^th International Conference on Nanotek & Expo

December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Reju George Thomas

Posters: J Nanomed Nanotechnol

Abstract:

Hyaluronic acid (HA) is a non-sulfated glycosaminoglycan organic polymer, found as structural component of the extracellular matrix (ECM) in mammalian bone marrow and loose connective tissues of our body. Hyaluronic acid also plays a major role in cell proliferation, motility, cell adhesion and gene expression. Cellular HA receptors such as CD44+ and RHAMM are over expressed in cancer which makes it a good candidate for tumor targeting purpose. Here we have developed a T1 gadolinium contrast agent based on Hyaluronic acid (HA) that target CD44+ receptor over expression in cirrhosis which also display higher relaxation property than primovist and better contrast?to?noise ratio (CNR) at 20 min and even at 2 hr time period. Superparamagnetic iron oxide nanoparticles (SPION) have emerged as an MRI contrast agent primarily for tumor imaging due to their efficacy and safety, proven by clinical application with a series of marketed SPION-based contrast agents. For the purpose of tumor diagnosis iron oxide nanoparticle coated with Hyaluronic acid (HA-SPION) as T2 contrast agent was synthesized with co-PEGylation strategy for increased bioavailabilty to tumor region. And finally, hyaluronic acid micelle that can encapsulate hydrophobic anti-cancer drug such as paclitaxel that specifically target CD44+ overexpressing tumor are synthesised which can act as promising drug delivery vehicle.

Biography :

Reju George Thomas has completed his MTech in Nanotechnology from Amrita Institute of nanosciences and molecular medicine (ACNSMM), India from 2010- 2012. At present he is pursuing PhD under Prof. Yong Yeong Jeong developing Theranostic nanoparticles and conducting pre-clinical testing at Clinical vaccine R&D centre of Chonnam National University Hwasun Hospital.