Brain Disorders & Therapy

The study of small world network in the patients with concussion and diffuse axonal injury

3^rd International Conference on Neurological Disorders and Brain Injury

April 18-19, 2017 London, UK

Yan Yan, Yao Shun, Cao Chenglong, Liao Wei, Song Jian and Xu Guozheng

Wuhan General Hospital of PLA, China

Posters & Accepted Abstracts: Brain Disord Ther

Abstract:

Objective: Brain functional network is constructed to analyze the properties of small world network in patients with concussion and diffuse axonal injury by resting functional magnetic resonance imaging (fMRI). Method: 13 patients with concussion, nine patients with diffuse axonal injury and 14 healthy controls were collected to test the resting fMRI. The collected data was labeled brain areas by AAL90 and Dosenbach160 after pretreatment. The correlation coefficients of the brain regions were calculated and constructions of N*N matrix were founded in specified sparsity. To study its small world and areas under curve of network parameter were calculated. Variance analysis was used to distinguish the differences of the two groups. Results: In given threshold, the brain network of patients with concussion, diffuse axonal injury and normal subjects were in line with the characteristics of small world, and a higher situation of global efficiency, local efficiency and average connectivity degree (p<0.05) were presented in patients with concussion and a lower situation of global efficiency, local efficiency and average connectivity degree (p<0.05) were presented in patients with diffuse axonal injury. Conclusion: The brain network of patients with concussion or diffuse axonal injury still has a characteristic of small world, but the global efficiency, local efficiency and the average degree of the patients can be higher or lower which may be caused by compensation or de-compensation.

Biography :

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