Indexed In
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- Ulrich's Periodicals Directory
- RefSeek
- Hamdard University
- EBSCO A-Z
- Directory of Abstract Indexing for Journals
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
The study of diagnostic ultrasound associated with microbubbles to open the blood brain barrier of rat
International Conference on Regenerative & Functional Medicine
November 12-14, 2012 Hilton San Antonio Airport, USA
Yi Song
Scientific Tracks Abstracts: J Stem Cell Res Ther
Abstract:
To explore the safety and effectiveness of diagnostic ultrasound associated with microbubbles to open the blood brain barrier (BBB). Microbubbles were injected through caudal vein, the rat head was radiated by GE Vivid 7 diagnostic ultrasound immediately. The radiated depth was located in the basal ganglia assisted by magnetic resonance imaging (MRI) scanning. The degree of BBB opening was evaluated by enhanced MRI and Evans blue dyeing. The safety was inspected by observation of cell morphology under hematoxylin eosin (HE) staining. Results: The rat head was radiated by diagnostic ultrasound with microbubbles, signal enhancement of the radiated area was observed on post contrast T1-Weighted images. Red fluorescence of Evans blue was detected by fluorescence microscope in the same area. Normal cellular morphology and structural integrity were showed by HE staining. Conclusion: The BBB of rat could be opened targetedly and noninvasively by diagnostic ultrasound associated with microbubbles. This may provide a new strategy for the drugs and stem cells treatment in the central nervous system diseases.