Health Care : Current Reviews

The pathophysiological roles of peroxynitrite in salt-sensitive hypertension

Joint Event on 3^rd International Conference on Medical Sciences, Hypertension and Healthcare and World Congress on Organ Transplantation and Artificial Organs

August 24-25, 2018 Tokyo, Japan

Dewan Syed Abdul Majid

Tulane University School of Medicine, USA

Posters & Accepted Abstracts: Health Care Current Reviews

Abstract:

Normally, superoxide (O2-) remains at minimal levels in tissues as it reacts with nitric oxide (NO) to form peroxynitrite (ONOO??). Although studies have demonstrated a reciprocal regulation of renal tubular sodium (Na+) reabsorption by NO and O2-, the specific role for ONOO?? in the regulation of renal sodium excretion is not yet clearly defined. It has been demonstrated that an interaction between NO and O2- forming ONOO?? plays an important reno-protective role in the kidney which helps to prevent excessive tubular Na+ reabsorption in conditions such as in elevated renin-angiotensin system. However, its regulation in various pathophysiological conditions, particularly in salt sensitive hypertension is not yet clarified. ONOO?? formation is increased by Angiotensin II (AngII) as well as by High Salt (HS) intake as both of these stimulate both NO and O2- production. However, conditions such as impairment in NOS activity, its pharmacological inhibition or gene deletion, reduces the formation of ONOO??. Recent findings show that chronic AngII with HS intake result in aggravated hypertension and renal injury in endothelial NO synthase knockout mice (a model for minimal ONOO?? formation) compared to those in wild-type mice that suggest a protective role for ONOO?? in these adverse effects of AngII. This talk will present evidence from different studies in our laboratory and others implicating the functional roles of ONOO?? in a coordinated regulation of kidney function, an imbalance of which could be involved in the patho-physiology of salt-sensitive hypertension.

Biography :

E-mail: majid@tulane.edu