Journal of Blood Disorders & Transfusion

The MPNs as a human inflammation model for cancer development

4^th International Conference on Blood Malignancies & Treatment

April 18-19, 2016 Dubai, UAE

Hans Hasselbalch

University of Copenhagen, Denmark

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms, in which a stem cell lesion induces an autonomous proliferative advantage. In addition to the JAK2V617 mutation several other mutations have been described. Recently chronic inflammation has been proposed as a trigger and driver of clonal evolution in MPNs. Herein, it is hypothesized that sustained inflammation may elicit the stem cell insult by inducing a state of chronic oxidative stress with elevated levels of reactive oxygen species (ROS) in the bone marrow, thereby creating a high-risk microenvironment for induction of mutations due to the persistent inflammation-induced oxidative damage to DNA in hematopoietic cells. Alterations in the epigenome induced by the chronic inflammatory drive may likely elicit an �??epigenetic switch�?� promoting persistent inflammation. In this presentation, all these issues and the perspectives of chronic inflammation as the driver of mutagenesis in MPNs will be discussed, including early intervention with interferon-alpha2 and potent antiinflammatory agents (e.g. JAK1-2 inhibitors, histone deacetylase inhibitors, DNA-hypomethylators and statins) to disrupt the self-perpetuating chronic inflammation state and accordingly eliminating a potential trigger of clonal evolution and disease progression with myelofibrotic and leukemic transformation.

Biography :

Email: hans.hasselbalch@gmail.com