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The Evaluation of Hepatitis C Virus Core Antigen in Immunized Balb/C Mice
5th Asia Pacific Global Summit and Expo on Vaccines & Vaccination
July 27-29, 2015 Brisbane, Australia
Mojgan Bandehpour
Posters-Accepted Abstracts: J Vaccines Vaccin
Abstract:
Hepatitis infection represents one of the important causes of morbidity and mortality in developing countries, however there is not any effctive vaccine against hepatitis C which is one of the signifiant problems in vaccine project. The aim of the present study is to evaluate the role of HCV core protein in inducing IFN-Gamma secretion and TCL activities as a vaccine in Balb/C mice. Our previous cloned plasmid (HCV Core gene into pETDuet-1) applied for protein expression in bacteria. The expressed and purifid recombinant protein together with Freund?s adjuvant was injected to 15 Balb/c mice. The total IgG and IgG2a of immunized mice sera were evaluated after a week. Two weeks after booster injection, we studied the proliferation and IFN? secretion of spleens, inguinal and popliteal lymph nodes lymphocytes by ELISA and ELISPOT. The FSFC (Frequency of spot forming cells) of secreting cells of immunized mice with HCV/Core protein and sera IgG2a were considerably higher than the control groups. The core protein together with proper adjuvant can be a candidate vaccine against of HCV infection.