Health Care : Current Reviews

The effect of metabolic syndrome on controlled ovarian stimulation outcome in infertile women with polycystic ovary syndrome: A prospective cohort study

International Congress on Global Healthcare

August 24-25, 2023 | WEBINAR

Tawoos Rezaee

Medical University Tehran, Norway

Scientific Tracks Abstracts: Health Care Curr Rev

Abstract:

Statement of the problem: Several studies demonstrated that polycystic ovary syndrome (PCOS) women have a higher risk of developing metabolic disorders which are related to obesity and metabolic features (1,2). One in four women in the United States is at risk of metabolic syndrome (MetS), and its incidence is developing every year (3). The complications of MetS have overlaps with obesity and PCOS which are linked to infertility and poor reproductive outcome (4). Therefore, the relationship between MetS and reproductive dysfunction is a debating issue for study (3, 5). Methodology & theoretical orientation: This prospective cohort study was conducted between November 2019 and November 2020 across two universityaffiliated infertility centers in Iran. The PCOS diagnosis was defined according to the Rotterdam criteria. The patients prior to assisted reproduction technology (ART) cycles were evaluated for MetS diagnosis. MetS was detected according to the National Cholesterol Education Program/Adult Treatment Panel III with the presence of at least three or more of the specific clinical criteria. The cycle outcomes were compared between MetS and non-MetS groups. Findings: Overall, 68 eligible infertile PCOS patients with MetS diagnosis and 126 without MetS participated. The MetS diagnosis was associated with the increased requirement for gonadotropins and the duration of controlled ovarian stimulation (COS) significantly (P=0.001). Although the total numbers of retrieved and MII oocytes, obtained and top-quality embryos as well as clinical pregnancy and live birth rates in the MetS group were lower than those of in the non-MetS group, the differences were not statistically significant (P>0.05). Among the obstetrics complications, the rate of preeclampsia was significantly higher in patients with MetS (P=0.02). Conclusion: MetS diagnosis in PCOS patients was associated with non-significant poor COS and pregnancy outcome. Further studies with larger sample sizes are recommended to clarify the risk of MetS in patients undergoing ART cycles.

Biography :

Tawoos Rezaee obtained her medical degree in 2004 from Fatimia-e-Qom University of Medical Science and received her obstetrics and gynecology specialty in 2017 from Kabul University, Afghanistan. She received her fellowship in infertility in 2021 from Tehran University of Medical Science. Her positions were: she was doctor in Kabul for 13 years and she was master in Kateb University of Medical Science for 2 years. She has experience in medical and surgical treatment of infertility, endometriosis, laparoscopy hysteroscopy, recurrent miscarriage and all assisted reproductive treatments.