Journal of Nanomedicine & Nanotechnology

Temperature-responsive PVCL-based hydrogel as a promising novel nanocarrier for drug delivery

14^th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology

April 09-11, 2018 Amsterdam, Netherlands

Elaheh Entezar-Almahdi, Fatemeh Farjadian and Soliman Mohammadi-Samani

Shiraz University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Among various dedicated nanoparticles for drug delivery applications, hydrogels have been mostly studied. Hydrogels are 3D structure with high water-content capacity that made up of hydrophilic polymers. In addition, hydrogels have significant physicochemical properties, such as permeability, porosity, physical interactions and some smart ones are capable to make response to environmental stimuli like temperature, pH and ionic strength. Poly vinyl caprolactam (PVCL) as one of the most extensively studied thermoresponsive polymer, has a continuous coil-to-globule phase transition behavior with the LCST ranging from 32 to 50°C, which depends on PVCL molecular weight and concentration. In this study, novel temperature responsive hydrogel based on Poly(vinylcaprolactam) (PVCL) were prepared via reversible addition-fragmentation chaintransfer (RAFT) polymerization, where PEG- diacrylate served as cross-linker, and lysine used as linking agent and applied for drug delivery. First, PVCL-PEG nano-hydrogel was prepared by RAFT polymerization in dioxane solvent, and then lysine added to PVCL-PEG. After that, doxorubicin as an anti-cancer drug, was conjugated to lysine moiety of as-prepared structure via Schiff-base reaction. Obtained nano-gels were characterized by FT-IR, 1H-NMR and their effective sizes were checked by dynamic light scattering analysis. LCST were determined and the drug release profile was tested in vitro. The 1H-NMR analysis of PVCL-PEG and PVCL-PEG-lysine confirm the synthetic steps. DLS analysis represents the particles hydrodynamic size with average diameter of 20nm. The LCST behavior was measured to lie at 37°C. Synthesized PVCL-PEG-lysine were observed to disperse well in aqueous solution without precipitation which show their high potential as a nanocarrier for drug delivery. elaheh.entezarmahdi@gmail.com