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Tangential flow filtration for the recovery of acellular pertussis vaccine components
29th International Conference on Vaccines and Immunization
March 19-20, 2018 | London, UK
Rakesh Kumar
Serum Institute of India Ltd., India
Posters & Accepted Abstracts: J Vaccines Vaccin
Abstract:
The commercial preparation of acellular pertussis vaccine depends on the effective recovery and purification of antigens pertussis toxin (PT), filamentous agglutinin (FHA) and pertactin (PRN) from Bordetella pertussis fermentation. This study describes the recovery of antigens using an open channel 0.45 micron tangential flow filtration module with optimization of process parameters of transmembrane pressure, cross flow and flux. Under the optimized conditions, greater than 98% recovery of PT and FHA was obtained.