Agrotechnology

Synthesis and biological activity of N-substituted 3-chloro-2-azitidinones/thiazolidines/tetrazoles

2^nd International Conference on Agricultural & Horticultural Sciences

Radisson Blu Plaza Hotel, Hyderabad, India February 03-05, 2014

M Swarna Kumari, L K Ravindhranadh and K Sudhakar Babu

Posters: Agrotechnol

Abstract:

3 -amino-1-(2,5-diflouro phenyl carbano thioyl) 4-(2-(4-(triflouro methyl)phenyl)hydrazono)-1H-pyrazoles-5(4H)-thione(1) on condensation with 4-substituted benzaldehyde(2) affored 3-(benzylidineamine)-1-(2,5-difluoro phenyl carbonothioyl)-4(2-(4- (trifluoro methyl)phenyl)hydrazono)-1H-pyrazole-5(4H)-thione(3). which on condensation with chloro acetyl chloride/mercapto acetic acid/PCl5, NaN3 and NaCl mixture yielded 3(1-(2,5-diflouro phenyl carbano thioyl)-5-thioxo- 4-(2-(4-(triflouro methyl)phenyl) hydrazono)-4,5 di hydro-1H-pyrazol-3-yl)-2-(4substituted phenyl azetidine-2-one /3(1-(2,5-diflouro phenyl carbano thioyl)-5-thioxo- 4-(2-(4-(triflouro methyl)phenyl)hydrazono)-4,5 di hydro-1H-pyrazol-3-yl)-2-(4substituted phenyl thiazolidine-4-one /1-(2,5-diflouro phenyl carbano thioyl)-3-(5-phenyl-1H-tetrazol-1-yl) 4-(2-(4-(triflouro methyl)phenyl)hydrazono)-4,5 di hydro-1H-pyrazol-5(4H)- thione respectively. The structures of newly synthesized compounds were established by IR, 1H-NMR, 13C-NMR Mass Spectral data and Analytical data. The newly synthesized compounds were screened for their anti bacterial activity against four micro organisms; Staphylococcus aureus (gram positive); Bacillus subtilis (gram positive); Pseudomonas aerugnosa (gram negative) and Escherichia coli (gram negative). They were found to exhibit good to moderate anti bacterial activity. The antifungal activities of these compounds were also tested against three different fungal species and none of them were active against the species tested.