Journal of Nanomedicine & Nanotechnology

Surface topography driven cell behavior for tissue engineering

4^th International Conference on Nanotek & Expo

December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Juseok Lee

Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Response of cells to the surface topography and the concept of contact guidance have been studied for decades. Various topographical features such as grooves, ridges, pores, wells and nodes in micro- or/and nanoscale have been presented to a wide variety of cells: fibroblasts, neuronal cells, macrophages, epithelial cells, endothelial cells, and smooth muscle cells. In this context, patterning of surfaces acts as an effective tool to control the cell adhesion, migration, orientation, shape, and even gene expression. In our approach, laser interference lithography was introduced to prepare micro hierarchical periodic patterns which are composed of chaotic nanowires to study cell-surface interaction of various cells. Firstly Al/Al2O3 coreshell nanowires were deposited on glass substrates by decomposing the single source precursor [tBuOAlH2]2 at elevated temperatures. Afterwards deposited layers were treated by a high energy pulsed Nd:YAG laser using two-beam interference technique. Neurons isolated from rat dorsal root ganglion, human umbilical vein smooth muscle cells, human umbilical vein endothelial cells and human stem cells were seeded and their responses on as-deposited and laser patterned Al/Al2O3 nanowires surfaces have been investigated. Our approach can contribute to the development of new biomedical applications such as bone and dental implants, neurochips, and cardiovascular stents.

Biography :

Juseok Lee received his BS in Materials Science and Engineering from Korea University of Technology and Education. He was awarded the Erasmus-Mundus scholarship for the interdisciplinary MS at both Lulea University of Technology (Sweden) and Saarland University (Germany) where he completed his PhD Since 2009, he works in INM?Leibniz Institute for New Materials (Germany) as a research scientist. His research focuses on nanoscale materials including nanowires and functional thin films as published in Chemical Society Reviews and Small. Currently he is head of Materials Science and Technology group of Korean Scientist and Engineer Association in Germany.