Journal of Bioequivalence & Bioavailability

Studying the effect of concentration of surfactants on the release of Ofloxacin from niosomes

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

S. Soumya and N.L Prasanthi

Posters: J Bioequiv Availab

Abstract:

N on-ionic surfactant vesicles (niosomes) containing an antibacterial drug ofloxacin were prepared by thin film evaporation by sonication method in different molar ratios of cholesterol and surfactant. The niosomes were prepared by using various nonionic surfactants such as Span 40, Span 80, Tween 20 and Tween 80. The prepared niosomes were characterized with respect to size distribution, drug entrapment efficiency, osmatic shrinkage and in vitro drug release profile. Niosomes were spherical with a size range of 0.5 to 5μm. The oleate chain (C 18 ) non-ionic surfactant vesicles showed highest entrapment efficiency than the lauryl chain(C 12 ) non-ionic surfactant vesicles. The cholesterol at 1:1 molar ratio found to have the highest entrapment efficiency. The in vitro results revealed that the release of the drug from niosomes by a diffusion controlled mechanism. The slow release observed from these formulations is beneficial for reducing the toxic side effects of ofloxacin. The methods employed for the preparation of the niosomes were reproducible with respect to the size distribution and percent drug loading values.