Journal of Nanomedicine & Nanotechnology

Study of nanoparticles based on using the unattached activity of radon progeny

2^nd International Conference on Nanotek and Expo

December 3-5, 2012 DoubleTree by Hilton Philadelphia Center City, USA

Lev Solomon Ruzer

Accepted Abstracts: J Nanomed Nanotechol

Abstract:

In this paper we discuss a proposed method for dose assessment of nanoaerosols, i.e., particles in the range of 1?100 nm. Nanometer aerosols are particles of extremely small sizes. A radioactive marker for these particles must be even smaller in size in order not to distort experimental results. We propose as an experimental tool the smallest radioactive nanoparticle, 1nm, called unattached activity of radon progeny. These particles form naturally by radioactive decay of the inert radioactive gas radon. The goal in these human experiments is to measure the local lung deposition of nanoaerosols by measurement of the gamma-activity of radon progeny. After inhalation of the mixture of monodispersed aerosols in the nanometer range, labeled with 1-nm unattached activity of radon progeny, which build up naturally due to radioactive decay of inert radioactive gas radon, the distribution of the gamma-activity in the lung is measured. Because each locally deposited nanopaticle is associated with measured gamma-quantum the gamma-activity itself quantitatively represent locally deposited nanoparticles, i.e., local nanoparticle dose. After inhalation the gamma-activity distribution in the lung represents local distribution of nanoparticles, since these particles are radiolabeled with radon progeny