Journal of Nanomedicine & Nanotechnology

Structural DNA nanotechnology: Liquid-crystalline approach

3^rd International Conference on Nanotek & Expo

December 02-04, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Yevdokimov Yuri and Mikhailovich

Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

The investigation of DNA-based materials attracts attention of scientists from various laboratories because this is definitely an emerging area in physics, molecular biology, biotechnology, biosensorics, nanobiotechnology as well as in material science. 1. Two different approaches in the structural DNA nanotechnology, i.e. ?hybridization? approach and ?liquid-crystalline approach? are compared. 2. The state-of-the art in the fundamental studies of liquid-crystalline state of double-stranded (ds) DNA molecules appeared as a result of their phase exclusion from polymer-containing water-salt solutions is described in detail. 3. The fundamental data obtained when studying the physico-chemical properties of ds DNA cholesteric liquid-crystalline dispersions (CLCD) were used as a background for the design of a few types of ?rigid? DNA nanoconstructions (NaCs). Two versions of liquid-crystalline approach to structural DNA nanotechnology, i.e. design of ?rigid? NaCs, using ds DNA molecules fixed within quasinematic layers of CLCD particles as building blocks, are considered. To realize the first version of liquid-crystalline approach, formation of artificial nanobridges in the ?free? space between ds DNA molecules was used. Second version of liquid-crystalline approach is based on the directed decrease in solubility of DNA molecules fixed within quasinematic layers of CLCD particles. The unique properties of the formed NaCs are demonstrated. The AFM studies of the various ?rigid? DNA NaCs allow one to draw some important evaluations. 4. Practical application of ?rigid? DNA NaCs carrying various ?guest? molecules is outlined.

Biography :

Yevdokimov Yuri. Mikhailovich Graduated from M. V. Lomonossov Moscow State University and was invited by Academician V. A. Engelhardt to Institute of Physico-Chemical and Radiation Biology of the RAS (former name for Institute of Molecular Biology). He did his Ph.D. in 1967 (Chemistry), attained a doctoral degree in 1991 (Chemistry), 1992 he became a Professor of Molecular Biology. He is the Head of the Laboratory ?Condensed State of Nucleic Acids? at Engelhardt Institute of Molecular Biology of the RAS. He is author and co-author more then 300 papers in the area of physical chemistry of nucleic acids, liquid crystals of nucleic acids and nanotechnology of nucleic acids published in the Russian and International journals. He is an Editorial Board Member of ?Open NanoScience? and ?Sensory Systems? (Russia) journals.