Pharmaceutica Analytica Acta

Standardized analytical technique for in-vitro performance testing of initial first line antihypertensive drugs in combination

18^th Annual Pharmaceutical and Chemical Analysis Congress

November 05-06, 2018 | Madrid, Spain

Deepak Sharma

GD Goenka University, India

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

JNC 2017 guidelines states the initial first-line therapy for hypertension is thiazide diuretics, calcium channel blockers (CCBs), and angiotensin converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs). Improved adherence can be achieved with once-daily drug dosing, rather than multiple dosing, and with combination therapy rather than administration of the free individual components. This research is to develop standardized analytical technique for in-vitro performance testing of initial first line therapy antihypertensive drugs (amlodipine besilate and enalapril maleate) in combined dosage forms by simultaneous equation method. The absorption maxima for UV detection were 237.20 nm and 217.00 nm for amlodipine besilate and enalapril maleate respectively, the dissolution media selected was 6.8 phosphate buffer and for 30 min, on USP II (Paddle) dissolution apparatus, at 50 RPM and at 37.0oC±0.5oC. The results of analysis were standardized statistically and by recovery studies. Linearity, accuracy and precision were acceptable in the ranges of 1-19?g mL-1 for amlodipine besilate and 1-9?g mL-1 for enalapril maleate. The results of cumulative percentage drug release (%CDR) were within the USP dissolution limits. The results of the studies propose this simultaneous equation method for the routine in-vitro performance testing of amlodipine besilate and enalapril maleate in combined pharmaceutical dosage forms (tablets).

Biography :

E-mail: deepak.sharma@gdgoenka.ac.in