Journal of Food Processing & Technology

Side effects of antioxidant quercetin over cancer therapy

4^th International Conference and Exhibition on Food Processing & Technology

August 10-12, 2015 London, UK

Zafer Akan1, Garip A I2 and Talha Muezzinoglu1

Scientific Tracks Abstracts: J Food Process Technol

Abstract:

The phytochemical quercetin is one of the most abundant dietary flavonoids widely present in many fruits and vegetables. Previous
in vitro studies has shown that quercetin acts as an antioxidant and anti-inflammatory agent and it has potential anti-carcinogenic
properties as an apoptosis inducer. In this study, it was examined apoptotic effects of quercetin on the K562 erythroleukemia cell
line. K562 cells were induced to undergo apoptosis by hydrogen peroxide. Cell viability and apoptosis level were assessed by annexin
V and PI staining methods using flow cytometry. Viability of K562 cells was increased by low dose of quercetin (5-100 μM) for 3
hours. Meanwhile, the toxicity of high doses of quercetin utilizing was proved in the conditions of 100-500 μM, 24 hours and resulted
in decreasing of K562 cell viability as expected (p<0.01). As a result, 100 μM quercetin was defined as a protective dose. Also, K562
cell apoptosis due to hydrogen peroxide was decreased in a dose dependent manner. As indicated in previous studies, reduction of
superoxides by free radical scavengers like quercetin could be beneficial for prevention of cancer but consumption of such flavonoids
during cancer treatment may weaken effects of chemotherapeutics and radiotherapy. Especially cancer patients should be carefully
considered for traditional phytotherapy during cancer treatment which can lead to controversial results.

Biography :

Zafer Akan has graduated from Yuzuncu Yil University, Faculty of Science, Department of Physics and MSc in the Yuzuncu Yil University School of Medicine, Department
of Biophysics and PhD in the Marmara University School of Medicine Department of Biophysics and University of North Carolina; Department of Biochemistry-Biophysics
NC USA at 2009. His main research area is Boron Neutron Capture Therapy for Soft tissue, Head and Neck Cancers. Moreover he has worked on antioxidants and cancer
relations. He is on the Editorial Boards of many international scientific journals. He is also a Chief Editor of International Journal Medical Science and Discovery.