Awards Nomination 20+ Million Readerbase
Indexed In
  • Academic Journals Database
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Ulrich's Periodicals Directory
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • MIAR
  • University Grants Commission
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
Share This Page
Journal Flyer
Journal of Bioequivalence & Bioavailability
Self-nanoemulsifying drug delivery system of Amisulpride: Optimization of formulation variables using central composite design
2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems
06-08 June 2011, Las Vegas, USA

Ahmed A. Aboelwafa and Amal Ibrahim

Scientific Tracks Abstracts: JBB

Abstract:

A misulpride is practically insoluble in water and suff ers from irregular and low bioavailability (48%). It is metabolized in liver to minor degree. Accordingly, this irregular and low bioavailability could be due to low solubility and P-glycoprotein effl ux which also aff ect its penetration through blood brain barrier. In the current study, in an attempt to solve these problems, Amisulpride self-nanoemulsifying drug delivery systems (SNEDDS) were prepared. Preliminary screening was carried out to determine Amisulpride solubility in various oils and surfactants. Th e formulations were prepared using oil (Caproyl-90), two surfactants (Cremophor EL and Labrasol, ?Smix?) and cosurfactant (Transcutol HP). Response surface methodology based on central composite design was applied for formulation optimization. Oil percentage, Smix: cosurfactant ratio and Cremophor EL: Labrasol ratio in Smix were selected as independent variables while mean droplet sizes at pH 1.2, 4.5 and 6.8, drug loading and absorbance of diluted SNEDDS at pH 1.2, 4.5 and 6.8 as dependent variables. A second-order polynomial equations were fi tted to data. Optimized formulation, containing 10% oil, 1.31 Smix: cosurfactant ratio and 2 ratio of Cremophor EL: Labrasol was prepared according to soft ware determined levels using desirability function and overlay plot. It provided a drug loading of 50.2 mg/ml and mean droplet sizes of 28, 120 and 95 nm in pH 1.2, 4.5 and 6.8 respectively. Also, it released Amisulpride completely within 15 min irrespective of the type or pH of dissolution medium. Bearing in mind that optimized SNEDDS incorporates bioactive ingredients, it could be potential for improving Amisulpride oral bioavailability