Journal of Bioequivalence & Bioavailability

Screening potential of biodegradable polymersomes for controlled drug delivery

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Shalaka. R. Patki, Kiran S. Patil and John. I. Disouza

Posters: J Bioequiv Availab

Abstract:

I n recent times, copolymerization of biodegradable polymers in order to obtain novel tailored hybrid materials for modified drug delivery is on a pace. The controlled drug delivery systems are of great significance amongst the available, due to the achievement of an optimum concentration, usually for prolonged time, and the diminishing of side effects due to the reduction of high initial blood concentrations. The preference for going for polymersomes over other nanostructured carriers include enhanced mechanical stability and greater flexibility to tailor bilayer characteristics such as thickness and chemical composition, enhanced stability of labile drugs, controlled drug release and an enhanced drug bioavailability owing to the fact that particles in the nano-size range are efficient in crossing permeability barriers. The objective of this research was to design polymer-based nanoparticulated carriers or polymersomes from block copolymers and screening polymersomes as drug delivery vehicles for controlled release mechanisms, and drug bioavailability. Physical blends of chitosan (CS) graft copolymers were devised and its polymersomes were prepared by solvent injection method. A poorly water soluble drug was successfully loaded into these polymersomes. Maximal encapsulation efficiency exhibited by the polymersomes was 72.5%. Formation of interpenetrating network and the chemical stability of drug loaded polymersomes was confirmed by Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy confirmed spherical shapes and smooth surface morphology of the polymersomes. In vitro release study showed that these polymersomes could control drug release for more than 24h and exhibited their potential as controlled drug delivery systems