Pharmaceutica Analytica Acta

Screening of novel oxazepines for anticonvulsant effect

International Conference on Bio-Pharmaceuticals, Biosimilars & Pharma Industry

February 28 - March 01, 2019 Osaka, Japan

Lincy Joseph

Pushpagiri College of Pharmacy, India

Scientific Tracks Abstracts: Pharm Anal Acta

Abstract:

Epilepsy is a neurological disease affecting people at all ages. In the disease burden epilepsy is in fourth position. With respect to magnitude, frequency and duration, the epilepsy experience varied individually. Mainly there will be deviation from normal conditions in movement, behavior, sensation, perception and consciousness. Oxazepine is oxygen and nitrogen containing seven membered heterocycle. With the aim of bringing a novel bioactive chemical pharmacophore for epilepsy at preclinical model, 25 oxazepine derivatives synthesized and their structures are confirmed through spectral analysis. Acute toxicity of the synthesized compounds done according to OECD 423 guidelines. Pentylenetetrazol at a dose level of 85 mg/kg (sc), used to induce convulsion in mice after 30 minutes of test drug treatment. Onset of convulsions and duration of convulsions noted. Maximal electroshock method also tried to find out the anticonvulsant effect of newly synthesized molecules. In the tested animals, current of 25 mA for 0.2 seconds applied through corneal electrodes. Protecting activity is considered as abolition of tonic extension. The change in degrees of anticonvulsant property varies with different functional group also discussed. Phenytoin has been used as the standard drug to compare the effects of test compounds.

Biography :

Lincy Joseph is currently working as Professor and HOD at Pushpagiri College of Pharmacy, India. She has completed her Post-doctoral studies at USA and France. She published more than 240 scientific research articles and authored different national and international text books.

E-mail: lincyjoseph2013@yahoo.com