Pharmaceutica Analytica Acta

Role of Globularia in the inhibition of calcium oxalate crystallization

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Mohamed Beghalia2,3, Aissa Belouatek2, Said Ghalem1 and Hocine Allali1

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Plant extracts are known to modulate calcium oxalate (CaOx) crystallization. One of these is Globularia, the root and flower. Medicinals plants have been demonstrated to be an efficient inhibitor of CaOx crystal growth; however, its inhibitory activity against other events in CaOx crystallization has not been fully investigated. To assess the potential of Globularia as an effective inhibitor, its effects on CaOx crystal nucleation and aggregation were evaluated. Nucleation and aggregation of CaOx crystals were studied by preparing artificial urine by mixing and stirring two equal volumes of 50 ml of solutions A and B at constant temperature (37?C). In the nucleation assay, crystallization was induced by mixing calcium chloride and sodium oxalate. The addition of extracts of Globularia flower and root, acts on the phase of growth crystallisation; the rate of inhibition capacity in concentration 100% is 96.09% and 96.77% for concentration 75% respectively. It was noted that these inhibitors developed an inhibition important on low concentration. Globularia is an efficient inhibitor of crystal nucleation and aggregation. Its presence in the kidneys and urine may protect subjects against CaOx crystallization and kidney stone formation.