Journal of Clinical & Experimental Pharmacology

RI-ADME study design of C-14 radiolabelled amoxicillin depletion in industrial animal using accelerator mass spectrometry

37^th World Congress on Pharmacology

October 31- November 01, 2024 Webinar

Beom Su Jang1* and Byung Yong Yu2

1Korea Atomic Energy Research Institute, South Korea 2Korea Institute of Science and Technology, South Korea

Scientific Tracks Abstracts: J Clin Exp Cardiolog

Abstract:

The presence of veterinary pharmaceutical residue in animal matrices for food is a major concern from a public health. Such hazards (residues) must be regulated through establishment of national or internationally acceptable regulatory standards and guidelines. Maximum residue limits (MRL): the maximum concentration of residue resulting from use of a veterinary drug that is acceptable in a food is well established as an international guideline, Currently accelerator mass spectrometry is well established with the highest sensitivity for the analyze of C-14 in the samples. Meanwhile recent evidence indicates that humans constantly exposed the antibiotics from livestock; however, whether these contaminants pose a substantial risk to human health is far from understood. The lack of crucial data on exposure and hazard represents key knowledge gaps that need to be addressed to move forward. Regulation is necessary and to establish internationally acceptable standards/guidelines, scientifically reliable data from depletion studies and associated analytical methods are required. For the development of amoxicillin-depletion study, we propose a RI-ADME study using accelerator mass spectrometry for the assessment of the long half-life radioisotopes such as C-14/H-3. Also we propose the nuclear imaging using SPECT for gamma emmiting radioisotopes and PET uses radiotracers that produce positrons. These advanced RI-ADME procedures could applied for the biologics more easily.

Biography :

Beom Su Jang has his expertise in evaluation of pharmacokinetic property of noble drug using radioisotope and nuclear imaging. Byeong yong Yoo has his expertise in application of accelerator mass spectrometry. They develop the new RI-ADME evaluation approaches based on accelerator mass spectrometry creates more powerful tools for improving C-14 analysis. They have built this model after years of experience in research, evaluation. The IAEA Coordinated Research Project (CRP): D52043 ‘Depletion of Veterinary Pharmaceuticals and Radiometric Analysis of their Residues in Animal Matrices’ support this study.