Journal of Bioequivalence & Bioavailability

Pulsatile drug delivery systems - single unit systems (Targeted drug delivery systems)

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Shiva Sai Goud. Kattikola and Murali Shyam.D

Posters: J Bioequiv Availab

Abstract:

P ulsatile drug delivery systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body .the principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. These systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, gastro-intestinal motility. The pre clinical studies have shown that pulsatile approach of delivering antibiotic is more effective. Different single unit capsular pulsative drug delivery systems have been developed. A general structure of such systems consists of an insoluble capsule body containing a drug and a plug. The pulsicap system under the capsular systems is the system which is made up of water-insoluble capsule body filled with formulation. The body is closed at the open end with a swell able hydro gel plug. Upon contact with the dissolution medium or gastro-intestinal fluids, the plug swells and after a lag time, pushes itself out of the capsule. This leads to drug release at a pulse. The lag time can be controlled by manipulating the dimensions and position of the plug .The port systems which is under Osmosis based capsular systems consists of a gelatine capsule coated with a semi permeable membrane. Inside the capsule was an insoluble plug and an osmotically active agent along with the drug formulation. When the capsule comes in contact with the dissolution medium water diffuses across the semi permeable membrane resulting in increased pressure inside that ejects the plug after a determined lag time. The lag time is controlled by coating thickness