Clinical Microbiology: Open Access

Preparation of nanolipogels for the delivery of hydrophobic drugs

Joint Event on 17^th International Conference on Pharmaceutical Microbiology and Biotechnology & 23^rd Edition of International Conference on Immunology and Infectious Diseases

April 29-30, 2019 London, UK

Bilal Mustafa

University of Strasbourg, France

Posters & Accepted Abstracts: Clin Microbiol

Abstract:

Nanolipogels (nLGs) are polymeric nanoparticles whose internal structure is a three dimensional network obtained by the crosslinking of polymer chains and swollen by an oil phase. nLGs have influenced different fields due to their three dimensional structure, controllable size, biocompatibility and good mechanical properties. Various methods have been proposed for the preparation of such nanogels, but most of them result in poor controllable size and broad size distribution. Here in, we propose a two-step low energy emulsification process to produce sizecontrolled nLGs that can modulate the release of an active substance. The first step aims at producing oil-in-water (O/W) nano emulsion through the spontaneous emulsification of a dispersed phase composed of the oily compound admixed with an acrylate monomer, a cross-linker, a photo-initiator and possibly the active substance. The oily nano-droplets size was found to depend upon the weight ratio between the surfactant and the oil phase (SOR). The second step consists of polymerizing the monomer by UV irradiation to generate the three dimensional polymer networks of the nLGs. Effects of the formulation parameters (SOR, type of monomer, weight fractions of monomer and crosslinker in the oil phase) on the nLG’s size and drug release properties have been thoroughly investigated and reported in the poster.

Biography :

E-mail: bmmemon@yahoo.com