Journal of Bioequivalence & Bioavailability

Preparation and in vivo evaluation of artemisinin-dextrin freeze dried powders

6^th World Congress on Bioavailability & Bioequivalence: BA/BE Studies Summit

August 17-19, 2015 Chicago, USA

Gamal Osman Elhassan1,2, Yuen Kah Hay3, Wong Jia Woei3, Jiauddin Khan4, Khalid Omer Alfarouq5, Akhter Javed1, Riyaz Khan1 and Kamal Querashi1

Posters-Accepted Abstracts: J Bioequiv Availab

Abstract:

Artemisinin (ART) is an oral antimalarial agent with poor aqueous solubility and low oral bioavailability. The present study
describes the preparation of artemisinin freeze dried powder using dextrin at different ratios, designed to enhance the solubility
of artemisinin and hence oral bioavailability. The resultant products were evaluated using relative bioavailability studies which were
conducted in Sprague-Dawely rats using the optimized formulation against the reference suspension. The effect of incorporation of
different co-carriers (citric acid or mannitol) to artemisinin-dextrin freeze dried powder at different ratio was evaluated. There was a
significant increase in the solubility and dissolution rate of artemisinin was obtained with the artemisinin-dextrin-citric acid freeze
dried powder at a ratio of 1:3:1. There was statistically significant increase in the oral bioavailability of freeze dried artemisinindextrin-
citric acid mixture compared to reference suspension. The rate and extent of absorption was enhanced by 3.4 folds. In
conclusion freeze dried product of artemisinin was able to increase solubility, dissolution and therefore the oral bioavailability.