Journal of Bioequivalence & Bioavailability

Preparation and evaluation of floating drug delivery system using natural polymers

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

M.V.N. Madhavi, P.Subhash Chandra Bose and Dr. R. Nagaraju

Posters: J Bioequiv Availab

Abstract:

N atural polymers and their derivatives are used widely in pharmaceutical dosage forms. These natural polysaccharides hold advantages over synthetic polymers, generally because they are non toxic, less expensive and freely available. Biopolymers can be modified to have tailor-made materials for drug delivery systems and thus can compete with synthetic biodegradable materials available in the market. Ghatti gum and karaya gum are natural polymers obtained as gum exudates. The aim of the present work was to study the effect of ghatti gum and karaya gum as carriers in developing floating tablets using Tramadol as model drug. Tramadol is a opoid analgesic. It acts as a weak agonist at all types of opoid receptors with some selectivity for the mu-receptors. The formulations were prepared by varying the concentrations of polymers under study. The tablets were prepared by direct compression technique using PVP K-30 as binder and sodium bicarbonate for development of CO2. The prepared formulations were evaluated for hardness, thickness, friability, weight variation, floating capability, dimensional stability, swelling studies, erosion studies and FTIR for its compatibility. In vitro dissolution was carried out in pH 1.2 HCl buffer at 37?1 ?C using basket type USP dissolution apparatus. The drug release from prepared tablets was found to be vary with vary in gum concentration. From the study it was concluded that floating drug deliver y system can be prepared by using the use of natural polymers as carriers