Journal of Bioequivalence & Bioavailability

Preparation and evaluation of controlled release carvedilol floating microspheres

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

L. Hithesha, L. Srinivas, K. Kavitha Sharma and T.S.N. Akhila

Posters: J Bioequiv Availab

Abstract:

The objective of the study was to prepare and evaluate carvedilol hollow microspheres for floating and controlled drug delivery. In the present investigation hollow microspheres of carvedilol using Cellulose acetate by Emulsion solvent diffusion technique were prepared and evaluated for their applicability as gastric retention systems.Hollow microspheres were prepared in different coat core ratios. The prepared hollow microspheres were discrete, spherical and free flowing. Low values of standard deviation in respect of drug content indicated uniform drug distribution in all the prepared batches. The encapsulation efficiency of the hollow microspheres was found to be in the range of 82-95 % in all the ratios of microspheres indicated the suitability of the method with minimum loss of drug during the process. The hollow microspheres were able to float for more than 24 hrs on the dissolution medium without floating lag time. This confirms their applicability as floating drug delivery systems. The IR and X-Ray diffraction spectroscopy studies revealed no interaction between the drug and the polymer used in the preparation of hollow microspheres. The SEM microphotographs showed the smooth texture of surface and the cross sectional view confirmed the hollow nature of the microspheres. The drug release from the hollow microspheres depended on the polymer concentration. From all the four ratios prepared the drug to polymer ratio 1:1 hollow microspheres showed consistent and controlled release over a period of 24 hrs compared to commercial sustained release tablet. The release of carvedilol from hollow microspheres followed zero order kinetics with diffusion mechanism.