Journal of Nanomedicine & Nanotechnology

Polyphosphonate ligands: From synthesis to design of hybrid PEGylated nanoparticles toward phototherapy studies

2^nd International Conference and Exhibition on Pharmaceutical Nanotechnology & Nanomedicine

March 20 - 21, 2019 | New York, USA

Jolanda Spadavecchia,Maelle Monteil,Hanane Moustaoui, Gennaro Picardi, Fatima Aouidat, Nadia Djaker, Marc Lamy de La Chapelle and Marc Lecouvey

University Paris, France Southwest Hospital, Third Military Medical University, China

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

The use of phosphonate ligands to modify the nanoparticle (NPs) surface has attracted strong interest in the last years for the design of highly functional hybrid materials. Here, we applied a methodology to synthesize bisphosphonates having functionalized PEG side chains with a specific length in order to design a novel class of hybrid nanomaterials composed by tetraphosphonatecomplex– gold COOH-terminated PEG-coated NPs (Bis-PO-PEGAuNPs). The synthetic approach consists in three steps: (1) Complexation between new phosphonate ligands (Bis PO) and tetrachloroauric acid (HAuCl4) to form gold clusters; (2) adsorption of COOHterminated PEG molecules (PEG) onto Bis PO-Au complex; (3) reduction of metal ions in that vicinity, growth of gold particles and colloidal stabilization. The obtained snow-shape-like hybrid nanoparticles have been characterized by ultra-violet/ visible, Raman spectroscopies, and electron microscopy imaging, involving their optical properties and photothermal activity in pancreatic adenocarcinoma cancer cells (PDAC).

Biography :

E-mail: jolanda.spadavecchia@univ-paris13.fr