Cardiovascular Pharmacology: Open Access

Polymorphism of candidate genes of cardiovascular diseases in children with connective tissue dysplasia

Joint Event on Heart Failure, Pediatric Cardiology & Nursing Education

February 18-19, 2019 | Amsterdam, Netherlands

T Filonova

Kharkiv Medical Academy of Post-graduate Education, Ukraine

Posters & Accepted Abstracts: Cardiovasc Pharm Open Access

Abstract:

Given the role of connective tissue dysplasia (СTD) in the formation of cardiovascular diseases in childhood, it is of interest to study the genetic risk factors associated with cardiovascular pathology, in children with undifferentiated CTD. Fifty children aged 5-17 years old were examined. The polymorphisms of the genes encoding angiotensinogen (AGTI T174M and AGTII M235T), endothelial NO synthase (NOS3 C-786T) and apolipoprotein E (ApoE L28P) have been studied. The obtained data: An increase in the proportion of homozygotes in the AGTI T174M allele T/T (68.6%), a heterozygote for AGTII M235T (68.6%), homozygote for NOS 3C allele T/T (48.6%) has been found in the group of children with cardiac dysplasia syndrome, cardiac complaints and documented ECG-changes. In the group of children without cardiac complaints and rhythm disturbances, an increase in the proportion of homozygotes in the AGTI T174M T/T alleles (53.3%) was also noted, but AGTII M235T homozygotes dominated T/T alleles (46.6%) and NOS 3C 786 T/T (66.7%). The ApoE L 28P genotype in the two comparator groups was almost identical and was presented by homozygotes in the L/L allele (97.2% and 93.4% respectively). Thus, study of the genetic markers of cardiovascular disease in children with CTD, is promising to clarify the diagnostic and prognostic criteria for the formation of cardiovascular pathology.

Biography :

T Filonova is a candidate of Medical Sciences. She is a Lecturer at the Department of Pediatrics of Medical Academy of Post-graduate Education in Kharkiv, Ukraine. Her specialization and the main practical and scientific interest include– children's cardiology (cardiac arrhythmia, cardiomyopathy, mitral valve prolapse) and echocardiography. She has been working in Pediatric Cardiology for over 30 years.

E-mail: tafilonova@gmail.com