Journal of Bioequivalence & Bioavailability

Polyelectrolyte surfactant complexes of Cefditoren Pivoxil for improved dissolution

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

M. Mounica, S. Soumya, M. SriDeepthi and L. Srinivas

Posters: J Bioequiv Availab

Abstract:

D rugs with low aqueous solubility will have low bioavailability on oral administration. Conversion of these drugs to an amorphous form leads to high water solubility but the amorphous form is thermodynamically unstable and therefore shows some tendency to crystallize and reduced oral bioavailability. Cefditoren pivoxil a cephalosporin antibiotic, which has low solubility in water and thus bioavailability is low on oral administration. The main objective of this work was to investigate the possibility of improving the solubility and dissolution rate of Cefditoren pivoxil by preparing stable polyelectrolyte surfactant complexes. The present study was planned to prepare polyelectrolyte polymer ? surfactant ?Cefditorenpivoxil drug dispersions using various polymers such as HPMC, PVP and PEG and sodium lauryl slfate as surfactant in different solvent systems. The polyelectrolyte surfactant complexes are prepared by solvent evaporation technique. These microparticles were characterized by infrared spectroscopy, X-Ray diffractometry and evaluated for the drug content, release characteristics. Promising results were obtained in the study, which indicates the applicability of polyelectrolyte surfactant complexes as a tool for improving stability, solubility and bioavailability of poorly soluble drugs