Journal of Nanomedicine & Nanotechnology

Polyelectrolyte coated clay nanotubes with pH controlled release

3^rd International Conference on Nanotek & Expo

December 02-04, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Lin Sun, Chris Boyer and David Mills

Posters: J Nanomed Nanotechnol

Abstract:

Halloysite nanotubes (HNTs) exist abundantly throughout the natural world and have versatile hollow tubular structures composed of two-layered aluminosilicates. The geometrical structure and surface charges of HNTs allow it to be loaded and nanocoated with a variety of materials, such as drugs and bioactive macromolecules and polymers, for sustained and extended releases. HNTs exhibit high levels of biocompatibility and very low cytotoxicity, making it an ideal candidate for new drug delivery systems. The incorporation of nanocoatings on HNTs offers more possibilities for target and trigger-responsive drug delivery platforms. Our previous studies have shown that the release time of drugs from HNTs can be extended and adjusted by the addition of polyelectrolyte nanocoatings. This study showed controlled pH-dependent releases of two model drugs, alizarin red (AZ), methylene blue (MB), and methotrexate (MX) from HNTs and polyelectrolyte multilayers including polyvinylpyrrolidone (PVPON), poly-acrylic acid (PAA), and polyacrylamide (PAM). Results showed that the stability of the nanocoatings and the release of drugs were greatly influenced by the pH of immersing solution and stock solutions. It is suggested that these molecular architectures have potential applications in nanoscale trigger-responsive drug delivery systems

Biography :

Lin Sun has completed his medical degree at the age 23 years from Zhengzhou University in China, and is currently a Ph.D. candidate at Louisiana Tech University for Molecular Science and Nanotechnology. He has presented at international conferences such as the 2013 Biomaterials Revolution in Massachusetts.