Journal of Aquaculture Research & Development

Pharmacokinetics of enrofloxacin in Exopalaemon carinicauda after oral and intramuscular administration

International Conference on Aquaculture & Fisheries

July 20-22, 2015 Brisbane, Australia

Qian-qian Zhai, Jian Li and Zhiqiang Chang

Posters-Accepted Abstracts: J Aquac Res Development

Abstract:

Many epizootic diseases are prevalent because of the high density aquaculture. Enrofloxacin is used to treat various systemic bacterial infections in aquatic animal. However, studies concerning the pharmacokinetics of enrofloxacin in Exopalaemon carinicauda which is important specie for polyculture in China are limited. Therefore, the pharmacokinetic profiles of enrofloxacin in E. carinicauda were investigated following a single oral and intramuscular administration (10 mg/kg body weight) at 20°C water temperature in this study. After drug administration the plasma and tissue samples (muscle, liver, and gill) were analyzed using an HPLC method. The results showed that the plasma concentration-time data for enrofloxacin were described commendably by a two-compartment open model with elimination half-life (t1/2?) of 20.38 and 17.76 hour after oral and intramuscular administration respectively. The t1/2? values are reasonable and suitable for one time a day dosing regimen to achieve good efficacy and reduce the risk of drug residues. The drug concentrations in all the tissues were peaked at 1 hour after oral administration and 0.5 hour after intramuscular administration and the highest drug concentration was in hepato pancreas followed by gills and muscle. As enrofloxacin is a typical concentration-dependent drug, the Cmax/MIC and AUC/MIC values were selected as indices to ensure its therapeutic efficacy in aquaculture. The plasma Cmax/MIC values were 15.95 and 19.86 and the plasma AUC/MIC values were 797.51 and 993.07 for enrofloxacin on aquatic animal pathogens such as Vibrio and Aeromonas after oral and intramuscular administration respectively. These ratios indicate it can obtain good therapeutic efficacy using the current dosage and mode of administration of enrofloxacin. This study would be helpful for the clinical regiment design of enrofloxacin in E. carinicauda and provide reliable basis for use of enrofloxacin in aquaculture that could improve the quality of aquaculture products.