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Pathogen-associated molecular patterns on biomaterials: A paradigm for engineering new vaccines
International Conference & Exhibition on Vaccines & Vaccination
22-24 Nov 2011 Philadelphia Airport Marriott, USA
Tarek M. Fahmy
Scientific Tracks Abstracts: J Vaccines Vaccin
Abstract:
Vaccine development has progressed signifi cantly since Jenner and Pasteur, moving from whole microorganisms towards subunit vaccines containing only their antigenic proteins. Since subunit vaccines are oft en less immunogenic than whole pathogens, adjuvants must amplify the immune response, ideally establishing both innate and adaptive immunity. Biomaterials, including liposomes, solid biodegradable polymers, and natural polymers, in vaccines promote appropriate responses. Th ese well-defi ned platforms feature easily manipulated physical properties, allowing for controlled delivery of antigen and immune stimulatory factors and the addition of pathogen associated molecular pa tterns (PAMPs) to target immune cells. Overall, modifying biomaterials engineers immune responses both quantitatively and qualitatively, considerably enhancing vaccine effi cacy. Here we discuss advances in both immunology and biomaterials that have brought biomaterial particulate-based vaccines to reality.