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Organic nano-cube delivery system for sustained release of encapsulated skincare actives
11th International Conference and Expo on Nanoscience and Molecular Nanotechnology
October 20-22, 2016 Rome, Italy
Youssry Y Botros
PanaceaNano, Inc., USA
Posters & Accepted Abstracts: J Nanomed Nanotechnol
Abstract:
The method of delivery of the active skincare ingredient in a topical cosmetic formulation determines the efficacy of the product. A green nanotechnology based on a new class of porous, sponge-like nanomaterials called organic nano-cubes (ONCs) that are comprised of carbohydrate molecules has been employed in cosmetic formulations. Organic nano-cube materials are biodegradable, edible, and non-toxic. Not only can the organic nano-cubes host and encapsulate active ingredients, such as skincare, anti-wrinkle, and anti-aging cosmeceuticals, for protection from photodegradation, they act as nano-carriers to enhance the dermal and transdermal delivery of these ingredients. Organic nano-cubes release the cosmetic ingredients directly into the skin undamaged and at a controlled rate for long-lasting treatment without the side effects of skin irritation resulting from uncontrolled exposure. The capability of ONCs to retain and release skincare ingredients has been investigated. Based on the results obtained for several active ingredients tested, ONCs increase the ingredient release duration by 5x at a steady rate. It is believed that ONCs, loaded with active ingredients, act as reservoirs to store and steadily release guest ingredients and extend significantly the duration of therapeutic effect. Various types of nanomaterials have been used for improving delivery in cosmetic products, such as liposomes, nanoemulsions, and nanocapsules. ONCs comprise another class of nanomaterials that can be employed by the cosmetics industry. They are safe, biocompatible, and have proved to be a versatile and viable platform for sustained release and enhanced delivery for a wide range of cosmeceutical ingredients.