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Optimization of up-streaming production process of acellular pertussis vaccine
6th Euro Global Summit and Expo on Vaccines & Vaccination
August 17-19, 2015 Birmingham, UK
Rakesh Kumar
Posters-Accepted Abstracts: J Vaccines Vaccin
Abstract:
Acellular pertussis vaccine requires fermentation, isolation and purification of antigenic components i.e. pertussis toxoid
(PT), filamentous haemagglutinin (FHA), pertactin (69kD protein), fimbrie 2 and 3. The number of doses per fermentation
batch of acellular pertussis vaccine is usually 20-25 times lower than whole cell pertussis vaccine. It is necessary to increase
the titre of antigenic components and final yield during process of acellular pertussis vaccine. This study includes selecting
the high titre strain of B. pertussis, optimization of growth medium and cultivation condition for maximum production of
these antigens. An increase in the productivity by employing fed – batch rather than the currently used batch cultivation of B.
pertussis could reduce the cost of acellular pertussis vaccine.