Journal of Nanomedicine & Nanotechnology

Optimization of bio-nano interface for improved outcome in nano medicne

7^th World Nano Conference

June 20-21, 2016 Cape Town, South Africa

B Devika Chithrani

Ryerson University, Canada

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

The interface between nanotechnology and biology needs to be well understood for improved outcome in medical applications. In other words, we need to know the interaction of nanoparticles with individual cells and tissue for improved outcome in diagnosis, imaging and therapeutic techniques. Among other nanoparticles, gold nanoparticles (GNPs) are emerging as a novel tool to improve existing cancer therapeutics. GNPs are being used as radiation dose enhancers in radiation therapy and as well as an anticancer drug carrier in chemotherapy. However the success of GNP-based therapeutics depends on their ability to penetrate and distribute homogenously in tumor tissue. In this work, multicellular layers (MCLs) were grown to model the post-vascular tumor environment. GNPs of 20 nm and 50 nm diameters were used to elucidate the effects of size on the GNP penetration and distribution dynamics. Though the GNPs were able to penetrate into the tumor tissue, their penetration was inversely proportional to the GNP size. Similar to in vivo tissue, the MCLs exhibited a much more extensive extracellular matrix (ECM) than monolayer cell cultures. This increased ECM created a barrier for NP transport. Smaller NPs penetrated better compared to larger NPs. This model tissue structures are better tools to optimize NP transport through tissue before using them in animal models. This work highlights the importance of both the improved tissue model provided by MCLs as well as the importance of GNP functionalization in cancer therapeutics. A multifunctional platform based on gold nanostructures holds an array of promising directions for cancer research.

Biography :

Email: devika.chithrani@ryerson.ca