Journal of Vaccines & Vaccination

Optimization of anti-cysticercosis S3Pvac vaccine and experiences on its extensive application in a taeniasis-cysticercosis control program

International Conference & Exhibition on Vaccines & Vaccination

22-24 Nov 2011 Philadelphia Airport Marriott, USA

Edda Sciutto

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

Taenia solium cysticercosis is major parasitic disease of global proportions that poses very serious threats to human. Vaccination of pigs, the only intermediate host, could hinder the parasite transmission, thus reducing the human infection and improving pork quality. A fi rst synthetic version of a vaccine (S3Pvac) constituted by three peptides (GK-1, KETc1, and KETc12; 18, 12 and 8 amino acids-long respectively) was developed and its effi cacy to prevent porcine cysticercosis was demonstrated on the fi eld. Later on, a second less expensive recombinant version of the vaccine expressed in fi lamentous phages was developed, fi eld- tested, and proved to eff ectively prevent porcine cysticercosis. Notwithstanding its effi cacy, the diffi cult logistics and high costs involved by parenteral vaccination of more than six-million free ranging, practically feral pigs in Mexico, perambulating in wide hostile areas of our diverse geography, are immense and render impractical the task. An oral vaccine, which could be administered by the pig owners, would deal successfully with these diffi culties and become a serious candidate for regional or nationwide application. Th us, S3Pvac was expressed in papaya calli, an adequate system for oral immunization. Later on, we reported for the fi rst time data supporting the usefulness of S3Pvac-papaya for oral immunization against T. solium porcine cysticercosis, using a cysticercosis experimental mo del in rabbits orally infected with Taenia pisiformis oncospheres. Currently, the effi cacy of S3Pvac-papaya against porcine cysticercosis is being tested on the fi eld

Biography :

Edda Sciutto obtained her M.Sc. and Ph.D. at IIB, UNAM, Mexico. She is full-time researcher and professor at IIB, on the immunologic traits of human and porcine cysticercosis, and head researcher of several projects regarding vaccination against pig cysticercosis. Additionally, Dr. Sciutto has leaded coordinate projects with national and international faculties and universities. Dr. Sciutto has been conferred with several national awards and honors