Journal of Bacteriology & Parasitology

Novel therapeutic effects of sesamin on type-1 diabetes-induced cardiac dysfunction

9^th Biotechnology Congress

August 31-September 02, 2015 Orlando,Florida, USA

Tran Duong Thuy

Ton Duc Thang University, Vietnam

Posters-Accepted Abstracts: J Biotechnol Biomater

Abstract:

Type-1 diabetes (T1D) is also called insulin-dependent diabetes or autoimmune diabetes. In particular, the pancreas produces insufficient insulin or because cells do not use insulin which makes blood glucose and urine glucose increase. Diabetes is a risk factor to increase the occurrence and severity of cardiovascular events. According to statistics, cardiovascular complications are the leading cause of death of 3/4 of the number of diabetic patients over 40 years old. Sesame (Sesamum indicum) is one of natural medicine which has been known with many functions for good health. Sesamin is a lignan extracted from the sesame seed, has many beneficial effects such as hypoglycemia, ameliorate lipid metabolism, antioxidant and hypolipidemic activity, reduced cholesterol and anti-inflammatory activity. In this study, after oral administration of Sesamin extract for four week, all the diabetes subjects underwent to blood glucose test, heart rate (HR), electrocardiography (ECG), blood pressure, hematoxylin and eosin stain to observe the effect of Sesamin on diabetes. Sesamin consuming slightly improved blood glucose levels in rats with type-1 diabetes. But it significantly ameliorated HR, blood pressure (BP) and QT interval in male diabetes rats. This indicated that Sesamin has a positive effect on reducing cardiovascular complications in diabetic animals.

Biography :

Email: duongthuy1108@gmail.com