Journal of Nanomedicine & Nanotechnology

Novel mussel-inspired Ti-6Al-4V surfaces with biocompatibility, blood ultra-drag reduction and superior durability

17^th International Conference and Exhibition on Nanomedicine and Nanotechnology in Healthcare

November 23-24, 2017 Melbourne, Australia

Fei Tang, Qi Li, Chunze Wang and Xiaohao Wang

Tsinghua University, China

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

In order to develop new Ti-based biomaterials with biocompatibility, blood ultra-drag reduction and superior durability, a novel fabrication combining simple electrochemical and chemical processes was proposed. After being modified by C14H19F13O3Si (FAS), a biocompatible TiO2-SiO2polydopamine composite surface on Ti-6Al-4V substrate was obtained. The biocompatibility was evaluated using a series of in vitro test, revealing that compared with Ti-6Al-4V alloys, the surfaces exhibited a number of bioadvantages such as anti-platelet aggregation, anti-bovine serum albumin protein adsorption, a lower hemolysis rate (~0.7%) and non-cytotoxicity (the cell viability >88%). The test of human micro-vascular endothelial cells (HMEC) cultured on the specimens for 48 hours showed better cell proliferation of the surface. Moreover, we explored the blood dynamic characteristics of titanium alloy substrate biomaterial for the first time, with a focus on the effects of dopamine-reactant concentration on blood flow resistance. The results showed that, compared to titanium alloy material, the TiO2-SiO2 surface modified by 4 mg mL-1 dopamine solution displayed the optimal blood drag reduction characteristics, reaching a 76% drag reduction. After a 2 m (800 meshes, 3500 Pa) sandpaper abrasion test, the surface still maintained a superior repellency of blood (contact angles>150o, sliding angles <10°). This practical method may expand the applications of biomedical implantation materials. Recent publications 1. Li Q, Tang F, Wang C, et al. (2017) Novel mussel-inspired Ti-6Al-4V surfaces with biocompatibility, blood ultra-drag reduction and superior durability. Materials Science and Engineering: C; 76: 1041-1047. 2. Li Q, Tang F, Wang C, et al. (2016) Facile fabrication of wear-resistant multifunctional surfaces on titanium alloy substrate by one-step anodization and modification with silicon dioxide nanoparticles. Journal of Sol-Gel Science and Technology; 80(2): 318-325.

Biography :

Fei Tang has received his Doctorate degree from Tsinghua University in 2003. He is an Associate Professor in Tsinghua University. He is currently the Deputy Secretary-General of the China Society for Micro-nanotechnology and the Director of the Office. He is a Guest Editor of the international journal AIP Advances and mainly engaged in material testing and analysis technology and equipment, micro-system design and technology, precision measurement and control technology, mechanical and electrical integration technology research.
Email:tangf@mail.tsinghua.edu.cn