Journal of Bioequivalence & Bioavailability

Novel floating and bioadhesive biphasic release tablets of repaglinide and glipizide for strategic and effective treatment of diabetes mellitus

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Dnyaneshwar D. Sapat, Chirag Patel and Shailesh S. Chalikwar

Posters: J Bioequiv Availab

Abstract:

D iabetes be of any kind is still one of the major threat to world in 21 st century. As diabetes mellitus needs combination of effective oral agents from different chemical classes to maintain adequate blood glucose level. Design, development and optimization of floating and bioadhesive biphasic tablet become a rational approach for the treatment of type-II diabetes mellitus. This system enhances patient compliance by reducing the repetitive administration, and may improve bioavailability. A 2 3 factorial design was employed using three factors viz. HPMC K4M (X 1 ), Na CMC (X 2 ), NaHCO 3 (X 3 ) were used as independent variables with two dependent variables which were: Percent cumulative drug release after 12 h (Y 1 ) and Floating lag time (Y 2 ) for formulating floating and bioadhesive tablets. This system contained immediate release layer of repaglinide (RPG) and floating bioadhesive sustained release layer of glipizide (GPZ) prepared by the direct compression technique. Drug-drug compatibility study was carried out by FTIR and DSC. Tablets were evaluated for buoyancy study, swelling study, adhesion retention period, and in vitro release Optimized formulation (C2) released more than 90% RPG within 30 min from immediate layer while 93.44% of GPZ was released at the end of 12 h with the floating lag time of 142 sec. The tablet remained buoyant throughout all studies. Kinetic release models were applied for all formulations and ?n? values obtained from Korsmeyer?Peppas. Stability study on optimized formulation was also done. All the studies conducted signifies clearly that approach used is well defined, studied accordingly and will serve a valuable mean to treat diabetic complications