Journal of Nanomedicine & Nanotechnology

Novel biocompatible and biodegradable hybrid polymer nanosystems for treatment of deeply located tumors

26^th International Conference on ADVANCED NANOSCIENCE AND NANOTECHNOLOGY

December 05-06, 2022 | Dubai, UAE

Tatiana E Sukhanova

Lebedev Institute of Synthetic Rubber, Russia

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

A large number of new biocompatible and biodegradable polymer nanosystems are synthesized and characterized based on water-soluble amphiphilic polymer molecular brushes, mixtures of polycaprolactone and polyvinyl alcohol, chitosan, hyperbranched polyamidoamines, modified succinyl chitosan, and inorganic ZnSe and Se nanoparticles. For the first time, these systems have been loaded with chemotherapeutic drugs - 5-fluorouracil and paclitaxel, and various photosensitizers. Systematic studies of the structuralmorphological, optical, hydrodynamic, electrochemical and biomedical properties of the developed nanomaterials using the original (integrated and interdisciplinary) approach, including diagnostics in the nano-, micro and macro levels, as well as use of a unique combination of experimental biomedical methods are performed. Recent Publications 1. Sukhanova, T.E., Vylegzhanina, M.E., Volkov, A.Y. et al. Comparative Study of Polymer Nanoparticles on the Basis of Caprolactone–Polyvinyl Alcohol Mixtures with an Encapsulated Antitumor Preparation by Atomic Force Microscopy, X-Ray Diffraction, and Dynamic Light Scattering. Tech. Phys. 64, 1729– 1737 (2019). 2. Samy M., Abdallah H.M., Ayoub M.M.H., Vylegzhanina M.E., Volkov A.Y., Sukhanova T.E. (2020) Eco-friendly route for encapsulation of 5-fluorouracil into polycaprolactone nanoparticles. Egyptian Journal of Chemistry. 63 (1):255-267. 3. Ahmed Eman H., Abdelhamid Ahmed E., Vylegzhanina M. E., Volkov A.Ya., Sukhanova T.E., Ayoub Magdy M. H. (2022) Morphological and spectroscopical characterization of hyperbranched polyamidoamine–zwitterionic chitosanencapsulated 5-FU anticancer drug. Polymer Bulletin. 79:137- 155.

Biography :

Tatiana E Sukhanova has completed her PhD in 1989 and Doctor of Science in 2000 from the Institute of Macromolecular Compounds RAS, St.-Petersburg, Russia. She was Deputy Director, now she is the Leading research scientist of FSUE “S.V. Lebedev Institute of Synthetic Rubber”, Russia. She has over 250 publications that have been cited over 636(Scopus)/1142(RSCI) times, and her publication H-index is 13 (WoS)/17 (RSCI).