Journal of Microbial & Biochemical Technology

Novel anti-biofilm agents can be used as adjuncts or alternatives to classical antibiotic treatment

International Conference and Summit on Industrial & Pharmaceutical Microbiology

October 17-18, 2016 Kuala Lumpur, Malaysia

Surajit Bhattacharjee, Manash Ch Das and Priya Gupta

Tripura University, India

Posters & Accepted Abstracts: J Microb Biochem Technol

Abstract:

Biofilms are communities of either homogenous or heterogeneous bacterial populations that are found to be remain in the matrix made up of extracellular polymeric substances secreted by constituent population. Biofilms of virulent bacteria form an integral part of their infection machinery. The bacteria residing in biofilms have enhanced extent of virulence and pathogenicity. For example, Pseudomonas aeruginosa can form biofilms in a wide variety of environmental conditions which can lead to chronic persisting infections. So to control the formation and development of biofilm becomes a major strategy to control bacterial infection. But the increase in virulence and resistance against known antibiotic also poses a problem in therapeutic designing of drugs. So, new strategies for prevention of biofilm formation are necessary. In this direction we are focused on the screening of new natural and indigenous compounds for their bioactivity and in turn their antibiofilm activity. In this direction we have screened a polyphenol compound Vitexin against two model biofilm forming organismsâ?? namely P. aeruginosa and Staphylococcus aureus. The compound has shown a very good antibacterial as well as anti bioiflm activity against both the tested species. Also we have tried to see the effect of combination therapy of the flavone in combination with low doses of two highly active antibiotics viz. Gentamicin and Azithromycin which have also shown very promising results. Also, our laboratory is working on another napthoquinone plumbagin which has shown antibacterial activity against P. aeruginosa, Vibrio cholerae and S. aureus. The combination therapy of plumbagin with gentamicin shows very high antibiofilm activity at low doses of both the compounds thus showing very high synergistic activity. So, we can hypothesize that to combat with the emerging issue of multi drug resistance we can look for alternative approaches of combination therapy wherein new natural compounds can be used along with low doses of known potent antibiotics to show promising results.

Biography :

Email: sbhattacharjee@gmail.com