Health Care : Current Reviews

Noscapine as an apropos medicament in alleviating symptomatic features in Polycystic Ovary Syndrome in RU486 induced experimental model of Wistar Rats

5^th International Conference on HEALTHCARE AND HEALTH MANAGEMENT

December 07, 2022 | Dubai, UAE

Anjali P

University of Delhi, India

Scientific Tracks Abstracts: Health Care Curr Rev

Abstract:

Polycystic Ovary Syndrome (PCOS) is a metabolic and complicated endocrine disorder seen in 5 to 15% of premenopausal women. Currently, one in five ~ 20% Indian women suffer from PCOS. It is characterized by hyperandrogenism, chronic anovulation, hirsutism and insulin resistance. Though the underlying cause in its pathophysiology is still not clear, but the derangement of the hypothalamic-pituitary-ovarian axis could be the significant aspect in its manifestation. In this study, female Wistar rats (200±10 g bwt), exhibiting regular estrous cycle received an oral dose of RU486 [20 mg/kg/day] for 13 consecutive days for establishing the PCOS induced conditions. Biochemical, histomorphometrical and apoptotic changes were observed in pre and post noscapine treated PCOS induced rats and checked for its credence. Further radiolabeling studies were performed with 99m Technetium labed noscapine which gave us an insight in localization of noscapine in ovarian and brain tissue of rats and bringing about its action probably via hypothalamic-pituitary-ovarian axis. It can be concluded that the RU486 model is appropriate for understanding the ovarian and metabolic features of human PCOS and noscapine has a potential to act as a therapeutic medicament for amelioration of PCOS induced condition.
Recent Publications :
1. Anjali Priyadarshani, Vanshika Madan, Labani, Perumal Jayaraj. October 2022 Veritable evaluation and inspection of PCOS and its apropos medicaments. Indian Journal of Biochemistry & Biophysics Vol. 59, November 2022, pp. 1039-1047
2. Riya Dahiya, Puneet, Sunil Kumar Dhiman and Anjali Priyadarshani. October 2022 A Comprehensive Review on Potential and Prospects of Traditional Medicinal Plants for management of Coronavirus Disease (COVID-19 Vantage: Journal of Thematic Analysis ISSN: 2582-7391 October 2022, Volume 3 Issue 2
3. Singh D, Dhiman SK, Kumar V, Babu R, Shree K, Priyadarshani A, Singh A, Shakya L, Nautiyal A, Saluja S. Crop Residue Burning and Its Relationship between Health, Agriculture Value Addition, and Regional Finance. Atmosphere. 2022; 13(9):1405.

Biography :

Anjali P has completed her PhD from Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi, INDIA (2003-2008). She is currently Associate Professor in Department of Zoology, Kirori Mal College, University of Delhi, INDIA and has teaching experience of 20 years. She has served as Convener of many societies in her University; Fine Arts and Photography, ECO CLUB, Gender Sensitization and associated with many other societies working for underprivileged. She secured position in Top 20% in Life Sciences twice All over India in Prestigious Council of Scientific and Industrial Research Fellowship (2002). Participated in many International and National Conferences and awarded certificate of excellence for Best Oral Presentation Award and Best Poster presentation awards for her work. Organized more than 50 Workshops related to Environment, Health and Science. He has over 10 publications in International and National Journals and few Book Chapters to her credit.