Journal of Vaccines & Vaccination

New tools in African Swine Fever Virus (ASFV) for vaccines development

9^th Global Summit and Expo on Vaccines & Vaccination

November 30-December 02, 2015 San Francisco, USA

Yolanda Revilla Novella

CSIC-UAM, Spain

Posters-Accepted Abstracts: J Vaccines & Vaccin

Abstract:

ASFV is a large DNA virus that infects monocytes/macrophages of different species of suids, causing economically important and frequently fatal ASF. Our group has described that ASFV deploys strategies to evade the hostâ??s defense systems, such as inflammatory and immune responses and cell death. We also demonstrated that ASFV regulates and redistributes the cellular machinery while impairing the production of cellular proteins. In fact, eIF4E/ 4G, besides ribosomes and mitochondria have been found close to viral factories. ASFV enters to the host cells by macropinocytosis, inducing actin polarization as well as EGFR, PI3K-Akt, Pak1 and Rac1 activation. Currently we characterize cellular and viral factors involved in the binding and entry process, targets for vaccine development. Despite the efforts done during the last decades to obtain a preventive vaccine against ASFV infection, we are still far to succeed. For this purpose, two approaches are currently achieved 1) development of ASFV deletion mutants as candidate vaccine strains, and 2) the identification of protective antigens and development of DNA/ protein vaccines.

Biography :

Email: yrevilla@cbm.csic.es