Brain Disorders & Therapy

New technique of brain protection in OHCA stroke and brain trauma by CO2 expansion to provide therapeutic hypothermia

3^rd International Conference on Neurological Disorders and Brain Injury

April 18-19, 2017 London, UK

Fontaine H Guy

Pitié-Salpêtrière Hospital, France

Keynote: Brain Disord Ther

Abstract:

Therapeutic hypothermia produced by evaporation of per fluorocarbon in the fossa nasalis in a flow of oxygen reported in a prospective multicenter study has demonstrated a tendency to improve outcome in out of hospital cardiac arrest. When I saw the experiments on pigs at the Weil Institute of Cardiac Care Medicine (WICCM), I was immediately convinced that another approach of cooling could be abrupt decompression of gas. After multiple experiments, I demonstrated that it was possible to obtain on the same model a drop of brain temperature similar to the work previously reported at the WICCM. However, the simultaneous work on infrared images on severed pig heads suggested that it was possible to cool the brain by the decompression of gas inside the mouth instead of the nose which looks to be an even less invasive and faster method on the field. The second major interest of this new technique seems to be its application in stroke also suggested by animal models. It was during these experiments that my wife watching TV beside me experienced an episode of cardiac arrest that I was able to diagnose immediately. I started cardio pulmonary resuscitation followed by defibrillation performed by an old but still working defibrillator that I kept in the basement of my house when the original study of the method of fulguration was completed. Before arrival of fire brigade, I used a bottle of compressed gas also available in the basement of my house and delivered the cooling gas at that time in the fossa nasalis. Despite a period of 6 minutes of no-flow, she was able to recover after five days of coma with absolutely no neurologic deficit. This fortuitous resuscitation using for the first time brain cooling by decompressed gas will be used for the first pilot study supported by the Schiller Company (Switzerland). It will start soon in the city of Lugano which is already famous for its highest success rate of resuscitation (50%).

Biography :

Fontaine H Guy has made 15 original contributions at the inception of pacemakers since early 60s. He has serendipitously identified Arrhythmogenic Right Ventricular Dysplasia in the late 70s. He has published more than 900 scientific papers including 201 book chapters. He was the Reviewer of 17 journals in Clinical and Basic Science. He served during five years as a Member of the Editorial Board of Circulation. He has been invited to give 11 master lectures of 90 minutes each during three weeks in the top universities of China (2014).

Email: guy.fontaine2@numericable.fr