Brain Disorders & Therapy

Neuroprotective and anti-inflammatory roles for neuregulins in ischemic stroke

Global Summit on Stroke

August 03-05, 2015 Birmingham, UK

Byron D Ford

Posters-Accepted Abstracts: Brain Disord Ther

Abstract:

Stroke is a leading cause of death and long-term disability in the US. Neuregulins are a family of structurally related
proteins that have shown promise in treating stroke. We demonstrated that a single, intra-vascular administration of NRG-
1 reduced ischemia-induced neuronal death in rat and mouse focal stroke models by ~90% with a therapeutic window of >12
hours using MRI, histological and neurobehavioral outcomes. Currently, we are evaluating the efficacy of NRG-1 for acute
neuroprotection and post-stroke neuronal repair using a novel non-human primate stroke model. NRG-1 is currently in a phase
III human clinical trial for heart failure and improved cardiac function in a phase II patient study. These findings could support
the development clinical studies using NRG-1 alone or in conjunction with other therapiessuch as thrombolytic compounds
for the treatment of patients with acute stroke.