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Near infra red laser stimulated gold nanorods as multifunctional theranostic carriers for combined chemo-photothermal therapy of hepatocellular carcinoma
Joint Meet on 29th International Conference on Nanomedicine and Nanomaterials & 24th World Nanotechnology Congress
April 26, 2021 | Webinar
Rida Fatima Saeed, Uzma Azeem Awan, Abida Raza, Shaukat Ali and Nosheen Akhtar
Department of Biological Sciences, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan NILOP Nanomedicine Research Laboratories, National Institute of Lasers and Optronics College, (PIEAS), Islamabad, Pakistan Medical Toxicology Lab, Department of Zoology, Government College University Lahore, Lahore-54000, Pakistan
Scientific Tracks Abstracts: J Nanomed Nanotechnol
Abstract:
Despite the exciting advances in cancer therapy, low efficacy and high dose-related side effects of anticancer drugs remains the dominant reason for cancer related mortality. The purpose of the current study was to fabricate biocompatible multifunctional drug loaded nano-moieties for co-therapy (chemo-photothermal therapy). Herein, we have developed an effective NIR-stimulus system, polyelectrolyte-poly (sodium-4-styrenesulfonate) coated gold nanorods (GNRs) containing doxorubicin (DOX) (PSS-GNRs-DOX) to enhance chemotherapy by combining with photothermal therapy. Near infra red (NIR 808 nm, power density = 1.5 W/cm2 for 2 min) laser irradiation cause hyperthermia due to GNRs, which enhanced drug release rate to the HepG2 cells. The PSS-GNRs nano-complexes were found to be biocompatible, thermo-stable and exhibited high drug loading capacity. Cumulative DOX release significantly increased after laser exposure compared to non-irradiated samples (p<0.05). In vitro cytotoxicity testing revealed that the PSS-GNRs DOX conjugated nano-complexes with NIR laser irradiation appear more efficient in cell inhibition than without laser exposure and doxorubicin alone. Thus, a combinatorial approach based on chemo and photothermal strategy appears to be a promising platform in cancer management.