Journal of Stem Cell Research & Therapy

Nanotechnological approaches towards negotiating solubility enhancement for Ivacaftor in treatment of cystic fibrosis

7^th International Conference and Expo on Cell and Stem Cell Research

June 28, 2023 | Webinar

Bhupendra G Prajapati and Akshay Parihar

Ganpat University, India

Keynote: J Stem Cell Res Ther

Abstract:

Cystic fibrosis can be regarded as a multisystem disease without having any cure. Disease management have advanced leading to progression in patient’s quality of life. Time being newer issues have been arising and posing challenges to the care givers. The faulty gene in cystic fibrosis is expressed throughout the epithelium but most of the morbidity is caused due to lung diseases. The dysregulated Chloride channel in the CFTR gene causes production of thick mucus that clogs the airway. Respiratory infections can be traced out appropriately with the help of pulmonary route of drug administration. Targeted dosage forms are now being made with high efficacy and low toxicity make them unique. A huge financial burden is imposed due to deaths caused by Inflammatory lung diseases. Most respiratory system-related diseases are directly or indirectly related to air pollution, changes in lifestyle and consistent microbial infections outbreak causing inflammation. Treatment of inflammatory lung diseases can be targeted via the lungs because of their unique features. Inhalation therapy can target them with the help of inhaled therapy. This Research aims to present the wide-ranging role of nanoemulsions in treating inflammatory respiratory diseases by increasing the solubility of BCS class II drugs. Our target was to enhance the solubility of Ivacaftor, which belongs to a class of CFTR potentiators and a BCS class II drug. The solubility enhancement was to be achieved with the help of formulation into a nanoemulsion. Nanoemulsion has the advantage of being a thermodynamically stable formulation. We used Tween 20 as a surfactant and Transcutol-p as a co-surfactant. The region of the emulsion was identified after the construction of a pseudo-ternary phase diagram. The formulation was optimized using Design Expert 13, and the final preparation was evaluated for stability. Recent Publications 1. Sharma R, Malviya R, Singh S, Prajapati B. A Critical Review on Classified Excipient Sodium-Alginate-Based Hydrogels: Modification, Characterization, and Application in Soft Tissue Engineering. Gels. 2023 May 22;9(5):430. 2. Bhattacharya S, Saindane D, Prajapati BG. Liposomal Drug Delivery and Its Potential Impact on Cancer Research. Anticancer Agents Med Chem. 2022 Aug 4;22(15):2671-2683. 3. Paliwal, H., Parihar, A., & Prajapati, B. G. (2022). Current State-of-the-Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems. Front. Nanotechnol. 4: 836674. 4. Neubauer AM, Sim H, Winter PM, Caruthers SD, Williams TA, Robertson JD, Sept D, Lanza GM, Wickline SA. Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging. Magn Reson Med. 2008 Dec;60(6):1353-61. 5. Prajapati, B. G., Jivani, M., & Paliwal, H. (2021). Formulation and optimization of topical nanoemulsion based gel of mometasone furoate using 32 full factorial design. Indian drugs, 58(06), 19

Biography :

Bhupendra Prajapati is a Professor in Department of Pharmaceutics, Shree S.K.Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. He has more than 20 years of academic and research experience, has published more than 100 research and review papers in international and national Journals. Under his editorial two book under process and he authored 20 book chapters in the field of novel drug delivery. He published two Indian patent and three applications under evaluation. He is a reviewer in three high impact journals and is on the editorial board of several scientific journals.