Journal of Nanomedicine & Nanotechnology

Nanoparticle interactions with cells for targeting nanomedicines and understanding potential impact of nanomaterials

4^th International Conference on Nanotek & Expo

December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Anna Salvati

Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Nanoparticles can enter cells easily and are trafficked actively by cells. This has opened up incredible opportunities for the potential application of nanoparticles in nanomedicine to transport drugs to specific locations. However, there is as yet little understanding on the processes involved in nanoparticle-cell interactions. Here, quantitative methods to study nanoparticle uptake and final fate inside cells and to guide the design of nanoparticles capable to target specific cell receptors will be presented. Also how the environment in which nanoparticles are found changes nanoparticle properties, affecting much of the subsequent interactions with cells will be shown. This has important consequences on nanomedicine, and also affects the impact that some nanoparticles can induce on cells. Furthermore, it was shown that cell cycle and cell division affect nanoparticle uptake and how this needs to be taken into account in order to discriminate effects of cell division from eventual nanoparticle export or degradation.

Biography :

Anna Salvati has completed her PhD in Chemistry in 2007 in the University of Florence, Italy. She then worked for several years in the Centre for BioNano Interactions in Dublin, Ireland, and has recently moved to Groningen University, Netherlands as an independent PI. She has been focused on the development of quantitative methods to control and understand nanoparticle-cell interactions for both nanomedicine and nanosafety. She has currently 37 papers and her work has been highlighted in several journals, including Nature Nanotechnology and Nature Reviews Drug Discovery.