Journal of Nanomedicine & Nanotechnology

Nanoemulsion concept for water-poor soluble anti-cancer drugs to improve therapeutic benefit

26^th International Conference on ADVANCED NANOSCIENCE AND NANOTECHNOLOGY

December 05-06, 2022 | Dubai, UAE

Bhupendra G Prajapati

Ganpat University, India

Keynote: J Nanomed Nanotechnol

Abstract:

The lipophilic nature of the majority of newly developed anticancer drugs has resulted in poor bioavailability and pharmacokinetic variations (BCS II or IV drugs). Nanoemulsion formulations are becoming an effective delivery system for poorly water-soluble drugs. The term "Nanoemulsion" refers to a thermodynamically stable isotropically clear dispersion of two immiscible liquids, such as oil and water, stabilized by an interfacial film of surfactant molecules. The Nanoemulsion is formed readily and sometimes spontaneously, generally without highenergy input. The method of preparation of nanoemulsion includes high-pressure homogenizer or ultrasonication or microfluidization as part of the high-energy method. In the low energy category or condensation method, scientists had applied phase transition and spontaneous emulsification. The formulation consists of the surfactant, the oil phase and the water phase. In some of the cases, co-surfactant or co-solvent is also used to improve the formulation stability and increase drug loading. The systems are characterized based on globule size and its distribution, surface charge, dispersion/aggregation state etc. In many cases to improve stability anhydrous emulsion or solid self-emulsified systems developed. Overall, nanoemlsion is proven to be an important and effective tool to improve the bioavailability of water-poor soluble drugs.
Recent publications :
1. Bhattacharya S, Saindane D, Prajapati BG. Liposomal Drug Delivery and Its Potential Impact on Cancer Research. Anticancer Agents Med Chem. 2022 Aug 4;22(15):2671-2683.
2. Paliwal, H., Parihar, A., & Prajapati, B. G. (2022). Current State-ofthe- Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems. Front. Nanotechnol. 4: 836674.
3. Neubauer AM, Sim H, Winter PM, Caruthers SD, Williams TA, Robertson JD, Sept D, Lanza GM, Wickline SA. Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging. Magn Reson Med. 2008 Dec;60(6):1353-61.

Biography :

Bhupendra Prajapati is a professor in Department of Pharmaceutics, Shree S.K.Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. He has more than 20 years of academic and research experience, has published more than 100 research and review papers in international and national Journals. Under his editorial two book under process and he authored 20 book chapters in the field of novel drug delivery. He published two Indian patent and three applications under evaluation. He is a reviewer in three high impact journals and is on the editorial board of several scientific journals.